COVID-19 has accelerated many changes that increase consumer demands for health products, especially immunity-boosting food and drink. 54% of global consumers say that, have spent time educating themselves on ingredients and procedures that can boost their immune health. (1)
Sleep is a crucial biological process, and has long been recognised as an essential determinant of human health and performance such as the immune system and mental wellness. Recently, Millions of people were suffering from stay-at-home orders due to Social distancing, working-from-home. They are trying to maintain their daily life as well with good sleep. Most people are not on the lack of sleep time, they recognize the mental or physical disorder occurred by lowest sleep quality.
Sleep is a complex physiological process, currently, all researchers agree there is no signal physiological role sleep.however, Commonly, The definition of sleep relies on activity and metabolism in relation to the electrical brain signals obtained in the electroencephalogram (EEG). For example, human sleep is classified with 3 defined sub-states of non-rapid eye movement sleep (NREMS) including stage N1,N2, and N3, which are associated with increasing depth of sleep, slower EEG waves and rapid eye movement sleep (REMS). Human sleep cycles between NREMS and REMS for approximately 90 minutes for about four to five times during the night in an ultradian cycle. (** Non-rapid eye movement (NREM) also known as quite sleep, Rapid eye movement (REMS) also known as active sleep or paradoxical sleep.) (2)
Table 1. Electroencephalogram (EEG) power bands.
** EEG frequency bands provide essential information of how brain regions, cells, and molecules regulate wakefulness, sleep states and display dysfunction due to related pathologies.
According to studies, GABAA (gamma-aminobutyric acid A) receptor is initial sleep responses to peripherally administered modulators and agonists.(3)GABAA receptor antagonists enhance wakefulness while GABAergic receptor agonists promote NREMS. Moreover, GABAA receptor agonists, including benzodiazepines,barbiturates,imidazopyridines, and cyclopyrrolones, enhance NREMS.(4)
Based on the study of Anti-anxiety and hypnotic effects, L.citriodora and verbascoside exhibit anxiollytic hypnotic and muscle relaxant effects at the highest doses through interaction with GABAA receptor. (5) Recently, PLX( Lemon verbena, Lippia citriodora extract) recognized the function of sleep quality through study(n=28, 3weeks, 400mg/day).
Monteloeder offers high quality of Lemon verbena extract (Lippia citriodora or Aloysia triphylla), PLX
You can see the detailed information of PLX from the previous article related to sleep quality and anxiety.
https://www.monteloeder.com/lemon-verbena-a-natural-alternative-to-contrast-insomnia-and-anxiety/
In South Korea, Ecklonia cava extract 500mg/d, Hydrolysed casein protein 300mg/d Oryza sativa (gamma-oryzanol 4.4mg/g) 1g/d wear an individual Functional health claim for sleep quality. And also, Chamomile(Matricaria recutita), Hop(Humulus lupulus), Lavender (Lavendula officinalis), Passion Flower (Passiflora incarnata), Lime flower (Trilia spp.), Valerian (Valeriana officinalis)Jamaica Dogwood(Piscidia piscipula), Lemon Balm (Melissa officinalis), Pasque Flower (Anemone pulsatila) Wild Lettuce(Lactuca virosa), Skullcap(Scutellaria lateriflora) etc. were a herb therapy for sleep quality and apnoea based on traditional or scientific evidences.
Monteloeder offers below.
- ML0030-SE1699 Chamomille flower extract
- ML0095-SE1242 Hops strobile extract
- ML0121-SE1635 Lavender Oil
- ML0147-SE0097 Passiflora extract
- ML0114-SC0036 Valerian root extract
- ML0031-SC0114 Lemon Balm leaf extract
On the other hands, The market accessed with the Natural sources of Melatonin from Huang-qin (Scutellaria biacalensis), St.John’s Wort (Hypericum peforatum) flower etc. but Mostly, Prunus cerasus(Tart Montmorency Cherry) has produced many of sales and popular in sleep quality market of Korea.
Sources:
- Source: Innova Database Innova Consumer Survey 2020. Average of UK, US, Spain, France, Brazil, India, Germany, Mexico, China and Indonesia
- Mark R. Zielinski(2016), Functions and Mechanisms of Sleep, AIMS Neurosci. 2016 ; 3(1): 67–104. doi:10.3934/Neuroscience.2016.1.67.
- M Lancel (1999) Role of GABAA receptors in the regulation of sleep: initial sleep responses to peripherally administered modulators and agonists. Sleep, Volume 22, Issue 1, January 1999, Pages 33–42,
- Gottesmann C. GABA mechanisms and sleep. Neuroscience. 2002; 111:231–239. [PubMed: 11983310]
- Bibi Marjan Razavi (2017) Anti-anxiety and hypnotic effects of ethanolic and aqueous extract of Lippia citriodora leaves and verbascoside in mice.
