WHAT IS NUTROXSUN?
The Mediterranean is a region of high solar exposure. This has caused the indigenous plants to protect themselves from solar radiation through strong, efficient antioxidant defences.
Through years of research and development of the neighboring flora, the scientists from Monteloeder S.L. and Nutrafur have co-developed NutroxSun®, an exclusive combination of rosemary (Rosmarinus officinalis) and grapefruit extracts (Citrus paradisii), that protects, from the inside, the skin from sun-induced damage.
NutroxSun® is a suitable complement for topical sunscreen protection. Its effect is systemic, preventing and reducing photoinduced oxidation, skin photodamage, and photoaging.
The beneficial effects of NutroxSun® are scientifically supported by both preclinical and human studies performed by leading Universities and Clinical Research Organizations such as the University of Murcia and Miguel Hernandez University in Elche. The main studies performed are published in peer-reviewed scientific journals.
REFERENCES STUDIES PUBLISHED ON NUTROXSUN:
Nobile V, Michelotti A, Cestone E, Caturla N et al. Skin photoprotective and antiageing effects of a combination of rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradisii) polyphenols. Food Nutr Res. 2016. Jul 1;60:31871. (VIEW)
Pérez-Sánchez A, Barrajón-Catalán E, Caturla N et al. Protective effects of citrus and rosemary extracts on UV-induced damage in skin cell model and human volunteers. J Photochem Photobiol B. 2014 Jul 5;136:12-8 (VIEW)
UV RADIATION AND THE SKIN
Small amounts of ultraviolet rays (UV) are beneficial for the organism and is essential for Vitamin D production. However, prolonged exposure to solar radiation may result in acute and chronic health effects on the skin. Sunburn overexposure (erythema) is often the first sign of excessive exposure to these damaging rays, whilst long term consequences include photodermatitis, photoaging and ultimately various forms of skin cancer.
Long-term exposure to the sun’s UV rays can damage the skin´s fibers, causing the skin to sag, lose its elasticity and form fine wrinkles. Sun exposure also causes mottled pigmentation and a sallow yellow complexion, an overall uneven tone and discolouration. In fact, up to 90% of the visible changes commonly attributed to ageing may be caused by sun exposure.
UVB is the main culprit behind sunburn, while UVA rays, which penetrate the skin more deeply, are associated with wrinkling, leathering, sagging, and other light-induced effects of aging (photoaging). They also exacerbate the carcinogenic effects of UVB rays, and UVA-induced skin cancer is also becoming increasingly relevant. Consequently, an adequate photoprotection against both UVB and UVA is essential to control and prevent UV-related skin disorders.
Popular outdoor activities, recreational exposure or even a simple street walk can give rise to excess exposure to UV radiation.Two types of ultraviolet radiation, UVA and UVB, damage the skin, and both cause premature aging.
Skin photoprotection is traditionally referred to only topical sunscreens. The use of topical sunscreen alone often fails to provide reliable all-day protection for several reasons:
- Consumers generally do not apply correctly regarding quantity and forget to reapply every 2 hours.
- The average person only applies half to a quarter of the amount of sunscreen needed to achieve the SPF rating on the bottle. So a SPF 50 is more like an SPF 10 to 3 with the average application.
- Most people only apply when are actively seeking exposure, however 80% of sun exposure occur in normal daily life. UVA rays hold steady throughout the day and year.
- Even if well applied, topical photoprotection may neutralize only 55% of free radicals, the others continue to damage the skin.
- Effectiveness is affected by perspiration, washing, or rubbing.
- Therefore, adding a dietary approach to the topical product provides a more complete and efficient photoprotection.
HOW DOES NUTROXSUN WORK?
The phenolic compounds, diterpenes, and flavonoids contained in the rosemary and grapefruit extract work complementary and synergistically to counteract the negative effects of solar radiation.
GLOBAL ANTIOXIDANT PROTECTION. Nutroxsun® presents water-soluble antioxidants that quench and scavenge the first stage intracellular free radicals generated by solar radiation, thereby preventing oxidative damage of lipids, proteins, and DNA. Lipid-soluble anti- oxidants are also present that block the generation of lipoperoxy radicals due to cell membranes degradation and resulting in inflammation, protein degradation, and DNA damage.
ANTI-INFLAMMATORY ACTIVITY. Essential for the inhibition of successive tissue damage that occurs after UV irradiation.
PHOTOAGEING PREVENTION AND REPARATION. Inhibiting in a dose-dependent manner multiple skin Metalloproteinases (MMP-1; MMP-2; MMP-3; MMP-8 and MMP-12) that are responsible for excessive degradation of cutaneous structure components such as collagen, elastin, fibronectin, and laminin.
DNA PROTECTION. Decreasing the number of UVB-induced DNA breaks in human skin cells.
(*) Statistically significant when compared to 24 h.
24 h. after exposure to UVB light, skin redness increased about 40 % in all the groups. But only one hour later (25 hours) the group taking 250mg already showed a significant reduction in skin redness compared with its maximum level at 24 hours, while skin redness in the placebo group remained 4% higher. The 100mg group reported significantly reduced skin redness after 48 hours while the placebo group needed 72 hours before this was observed.
|A significant increase in the Minimal erythema dose (MED) – the threshold UV dose that may cause sunburn–was observed for NutroxSun® group; MED increased by 29.8% after 2 months of treatment. These ﬁndings conﬁrm earlier results obtained in a previous study where individuals consuming NutroxSun® presented a 34% increase in their MED after 2 months, rising to 56% after 3 months (J Photochem Photobiol B. 2014).||A significant decrease of UVA-stimulated lipoperoxide (LPO) content in the skin was observed. Skin horny layer malondialdehyde (MDA) content 4 h after UVA exposure was significantly decreased compare to placebo, in which a lipoperoxidation skin levels were increased.|
|A significant decrease in the wrinkle depth of the ‘crow’s feet’ was observed among subjects consuming 100 mg of NutroxSun daily. Wrinkle depth variation was statistically significant after 2 weeks and decreased approximately 15% after 2 months of treatment.||A significant increase of the skin´s elasticity was also observed among subjects consuming 100 mg of NutroxSun daily, and at the end of the study the net elasticity was improved by 9%|
The evidence is clear, but there´s more. Participants were also asked whether they noticed any improvements in their skin during the test and very interesting results were found. Self -assessment questionnaire main results:
NUTROXSUN® SUCCESS IN
DIFFERENT MARKET SEGMENTS
NURTOXSUN’S 100% NATURAL FORMULATION DELIVERS CLEAR CONSUMER APPEAL IN ALL MARKETS GLOBALLY.
SUCCESSFUL COMMERCIALIZED PRODUCTS CONTAINING NUTROXSUN ARE ALREADY AVAILABLE IN SEVERAL MARKETS WITH DIFFERENT PRODUCT POSITIONING (ANTIAGING AND PHOTOPROTECTION) AND PRESENTATIONS (CAPSULES, READY TO DRINK BEVERAGES, SHOTS, SOFT GEL CAPSULES OR EVEN EFFERVESCENT TABLETS).
NUTROXSUN IS ALSO AVAILABLE FOR TOPICAL COSMETICS AND SUNSCREEN.
Nutroxsun® is more than a clinically proven effective ingredient. Our partners have the opportunity to benefit from the use of our digital platform. Nutroxsun app is a tool designed to improve the consumer experience.
Give consumers your expertise and personalized support at a hand´s reach. Help them to a better use of your products and achieve the best possible outcomes. Increase your engagement and empower your brand’s trust demonstrating your products effects.
HOW DOES IT WORK?
Nutroxsun® APP is a sun exposure management app. The branding and functionalities can be fully customized to your needs. The Nutroxsun® APP works as a complementary service related to your product. Giving your brand visibility on the mobile world and the opportunity
to interact directly with your consumers, collecting valuable data and getting to know them better.
Our MVP (Minimum Viable Product) includes the
- User’s personal characteristics and context information
- Sun exposure budget calculation and management (automatically reduced considering UV exposure time and levels)
- Incorporation of topical and oral sun protection products (proper use and adherence, product effects tracking).
- Personalized recommendations based on product’s clinical studies and educational messages.