New article! Metabolaid and its effect on satiety

We are happy to announce that a scientific peer-reviewed article on Metabolaid has been recently published in the journal Food and Function.

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The new name of PLX: Move!PLX 

Our first branded ingredient PLX is a botanical extract powder from Lippia citriodora (Lemon Verbena, Aloysia Triphylla) that contains the highest verbascoside content with lemon verbena in the market. Lemon verbena have been reported in traditional medicines. The leaves of Lemon verbena are used for the treatment of fever, neuropathic and stomach pains, dizziness, headaches, hypnotic, anemia, migraine, and cold symptoms (1)

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Will Digital Health really save money in health spending?

Healthcare costs are climbing worldwide, irrespective of the geography, political organization, or any other condition. The challenges to solve in order to keep healthcare assistance sustainable are well known and  repeatedly analyzed, putting at the center of every analysis the ability to reduce costs of care and increase large-scale preventive actions, to counteract increasing age population.

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Digiceuticals for healthcare effective solutions

Mike Gibbs, president of OurPath Ltd., said: “The challenge of the 21st century is behavioral change. The diseases that are affecting us the most and crippling global healthcare economies are the ones caused by our own unhealthy lifestyles

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Monteloeder’s Digital Health solution for obesity: Metabolaid

Monteloeder has coined the concept of “Digital Nutraceutical”, which combines food & nutrition supplements with digital technology, resulting in a complete, personalized health solution.

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Digitally Reinforced Functional Foods: We are what we eat!

The internet opened the doors to spread and access information. Consumers are nowadays more informed and concerned than ever before about their health and wellbeing. The best healthcare is preventive healthcare.  Everything we eat, everything we do, can have an impact in our overall wellbeing.

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Personalization in healthcare: solution for the “holistically effective” approach

Today I came across with 2 studies published in high-impact factor journals [Cell group] giving opposite messages regarding the use of dietary supplements, due to unexpected interactions and influences on health conditions.

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging

– A positive effect of Nicotinamide mononucleotide (NMN), a molecule used in supplements for active aging since many years, on improving blood vessels functionality of old mice (comparable to 70-year-old humans), being a decline in capillary density and blood flow a major cause of mortality and morbidity. Interestingly, the molecular mechanism behind (that increased levels of the anti-aging enzyme SIRT1) is similar to workout and dietary restriction

The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells

– A negative effect of chondroitin-4-sulfate (CHSA), a natural glycosaminoglycan approved as a dietary supplement used for osteoarthritis, that selectively promotes the tumor growth of melanoma cells containing a specific genetic characteristic (mutation V600E of the gene BRAF) which is present in around 50% of melanomas. Not only this, it seems that it confers drug resistance to a commonly used anti-melanoma therapy (BRAF inhibitors).

Of course, these are only two examples of many studies regarding the (sometimes unpredicted) interactions between the use of supplements and health/disease conditions unrelated to their first indications. Dietary supplements contain a variety of ingredients, both natural herbal/botanicals and other categories (such as vitamins, minerals, amino acids), and in any case, it is important to understand their effects and effectiveness, because “natural” does not always mean “harmless” and “safe”1. It is actually very important to understand the label instructions, follow the healthcare providers advice (and tell them about any supplement you are taking) and trust only products with clear label statements and only from trusted manufacturers.

In the pursuit of effectiveness and safety, the healthcare trend towards Personalization will be relevant also in the Supplements field where an accurate and solid scientific background is necessary and must be always kept in mind along any step of product design and buyer journey. Indeed, a more comprehensive approach that takes into account not only the properties of any ingredient but also the eventual effects in different contexts is the safest and effective solution.

For example, as in the case of CHSA dangerous effect for a specific group of cancer patients, Genotype is an important piece of information to be considered to personalize both therapeutic treatments and dietary advice. However, it is reasonable to look for genetic information only if the “Biological plausibility” could apply: “a gene–environment interaction will only be accepted if it can be reproduced in two or more studies and also seems plausible at the biological level” [https://bit.ly/2pFwdjM]

The success of any Personalization approach resides in the use of a combination of any relevant information, as personal characteristics (genetics, age, anthropometrics, health status, family history) and context information, and never prioritizes any of them in isolation. I am confident that many relevant success stories, based on Personalization in wellbeing and healthcare, are coming and each one of us will be witness or main player in one or many of them!

Note 1: Easy-to-access basic information regarding dietary supplements could be found here and here (respectively from the US and European official Authorities websites).

Elisa Guida, PhD

Brand and Account Manager

The rise of personalized nutrition and digital technology

Nowadays we heard more and more about personalized nutrition, we even see a growing number of startups raising a lot of money based on the expectations that this individualized way of getting nutrients is creating, but can we say there is a commonly accepted definition to that? The answer is not. In essence, we all understand that since everyone is different our nutritional needs are also different, that’s why we need personalized nutrition. But the discrepancies come when we talk about which parameters should be considered to define a customized diet.

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Preventive Health: in the path of solving the nutrition/health equation

Traditionally, Nutrition Clinical studies have relied on the participants to tell them what they had eaten during the course of the study. Due to our human nature, this information was not always very accurate, or in some occasions downright false.

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